Drug Study – Erythromycin

Action:

Macrolide antibiotic produced by a strain of Streptomyces erythreus. Bacteriostatic or bactericidal, depending on nature of organism and drug concentration used.

Classification:

ANTIINFECTIVE; MACROLIDE ANTIBIOTIC

Indication:

Pneumococcal pneumonia, Mycoplasma pneumoniae (primary atypical pneumonia), acute pelvic inflammatory disease caused by Neisseria gonorrhoeae in females sensitive to penicillin, infections caused by susceptible strains of staphylococci, streptococci, and certain strains of Haemophilus influenzae. Also used in intestinal amebiasis, Legionnaires’ disease, uncomplicated urethral, endocervical, and rectal infections caused by Chlamydia trachomatis, for prophylaxis of ophthalmia neonatorum caused by N. gonorrhoeae, C. trachomatis, and for chlamydial conjunctivitis in neonates. Considered an acceptable alternative to penicillin for treatment of streptococcal pharyngitis, for prophylaxis of rheumatic fever and bacterial endocarditis, for treatment of diphtheria as adjunct to antitoxin and for carrier state, and as alternate choice in treatment of primary syphilis in patients allergic to penicillins. Topical applications: Pyodermas, acne vulgaris, and external ocular infections, including neonatal chlamydial conjunctivitis and gonococcal ophthalmia.

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