Mannitol – Drug Study

Brand Name: Osmitrol, Resectisol

Classification: Osmotic Diuretic

Action Summary

Half-life Onset Peak Duration
100 minutes 30-60 minutes 1 hour 6-8 hours


  1. Acute oliguric renal failure
  2. Toxic overdose
  3. Edema
  4. Increased intracranial pressure (ICP)
  5. Intraocular pressure (IOP)


  1. In the oliguric phase of acute renal failure, Mannitol increases osmotic pressure (pressure needed to stop the absorption of something or osmosis) of the glumerular filtrate, thereby, promoting diuresis (treating the oliguric phase of renal failure) and excretes toxic materials (management for toxic overdose).
  2. It also elevates blood plasma osmolality thus, inhibiting the reabsorption of water and electrolytes (for relief of edema) and mobilizing fluids in the cerebral and ocular spaces (lowers intracranial or intraocular pressure).


  1. Susceptibility
  2. Dehydration

Adverse reactions

  1. Dehydration
  2. Anuria
  3. Intracranial bleeding
  4. Headache
  5. Blurred vision
  6. Nausea and vomiting
  7. Volume expansion
  8. Chest pain
  9. Pulmonary edema
  10. Thirst
  11. Tachycardia
  12. Hypokalemia (increases the risk of digoxin toxicity)
  13. Chronic renal failure



Oliguria: 50-100 g as a 5-25% solution.

Intracranial/Intraocular pressure: 0.25-2 g/kg as 15-25% solution administered for 30-60 minutes.


Oliguria: 0.25-2 g/kg as a 15-20% solution for 2-6 hours

Intracranial/Intraocular pressure: 1-2 g/kg as a 15-20% solution administered for 30-60 minutes.

Nursing considerations

AssessmentMonitor the following:

  1. 1. Vital signs
  2. 2. Intake and output
  3. 3. Central venous pressure
  4. Pulmonary artery pressure
  5. Signs and symptoms of dehydration (e.g. poor skin turgor, dry skin, fever, thirst)
  6. Signs of electrolyte imbalance/deficit (e.g. muscular weakness, paresthesia, numbness, confusion, tingling sensation of extremity and excessive thirst)
  7. (for increase ICP) Neurologic status and intracranial pressure readings.
  8. (for increase IOP) Elevating eye pain or decreased visual acuity.

Laboratory Tests

  1. Renal function (BUN and Creatinine)
  2. Serum Electrolyte (Sodium and Potassium)


Pregnancy and lactation (safe use during these conditions is not established)


  1. Observe the IV site regularly for infiltration.
  2. Administration rate for oliguria should be titrated to produce a urine output. (about 30-50 ml/hr in adult and 2-6 hours in children)

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Daisy Jane Antipuesto RN MN

Currently a Nursing Local Board Examination Reviewer. Subjects handled are Pediatric, Obstetric and Psychiatric Nursing. Previous work experiences include: Clinical instructor/lecturer, clinical coordinator (Level II), caregiver instructor/lecturer, NC2 examination reviewer and staff/clinic nurse. Areas of specialization: Emergency room, Orthopedic Ward and Delivery Room. Also an IELTS passer.

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