Drug Study – Trimethoprim-Sulfamethoxazole (TMP-SMZ)
Bactrim, Co-Trimoxazole, Septra
Fixed combination of sulfamethoxazole (SMZ), an intermediate acting antiinfective sulfonamide, and trimethoprim (TMP), a synthetic antiinfective. Both components of the combination are synthetic folate antagonist antiinfectives. Mechanism of action is principally enzyme inhibition, which prevents bacterial synthesis of essential nucleic acids and proteins.
antiinfective; urinary tract agent; sulfonamide
Pneumocystis carinii pneumonitis, Shigellosis enteritis, and severe complicated UTIs due to most strains of the Enterobacteriaceae. Also children with acute otitis media due to susceptible strains of Haemophilus influenzae, and acute episodes of chronic bronchitis in adults.