Clopra, Emex , Maxeran , Maxolon, Reglan
gastrointestinal agent; prokinetic agent (gi stimulant)
Pregnancy Category: B


Assessment & Drug Effects

  • Report immediately the onset of restlessness, involuntary movements, facial grimacing, rigidity, or tremors. Extrapyramidal symptoms are most likely to occur in children, young adults, and the older adult and with high-dose treatment of vomiting associated with cancer chemotherapy. Symptoms can take months to regress.
  • Be aware that during early treatment period, serum aldosterone may be elevated; after prolonged administration periods, it returns to pretreatment level.
  • Lab tests: Periodic serum electrolyte.
  • Monitor for possible hypernatremia and hypokalemia (see Appendix F), especially if patient has CHF or cirrhosis.
  • Adverse reactions associated with increased serum prolactin concentration (galactorrhea, menstrual disorders, gynecomastia) usually disappear within a few weeks or months after drug treatment is stopped.

Patient & Family Education

  • Avoid driving and other potentially hazardous activities for a few hours after drug administration.
  • Avoid alcohol and other CNS depressants.
  • Report S&S of acute dystonia, such as trembling hands and facial grimacing (see Appendix F), immediately.
  • Do not breast feed while taking this drug without consulting physician.

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