AMOXICILLIN AND CLAVULANATE POTASSIUM
Augmentin, Augmentin-ES600, Augmentin XR, Clavulin
Classifications: antiinfective; beta-lactam antibiotic; aminopenicillin
Pregnancy Category: B
Assessment & Drug Effects
- Determine previous hypersensitivity reactions to penicillins, cephalosporins, and other allergens prior to therapy.
- Lab tests: Baseline C&S tests prior to initiation of therapy; start drug pending results.
- Monitor for S&S of an urticarial rash (usually occurring within a few days after start of drug) suggestive of a hypersensitivity reaction. If it occurs, look for other signs of hypersensitivity (fever, wheezing, generalized itching, dyspnea), and report to physician immediately.
- Note: Generalized, erythematous, maculopapular rash (ampicillin rash) is not due to hypersensitivity. It is usually mild, but can be severe. Report onset of rash to physician, since hypersensitivity should be ruled out.
Patient & Family Education
- Female patients should report onset of symptoms of Candidal vaginitis (e.g., moderate amount of white, cheesy, nonodorous vaginal discharge; vaginal inflammation and itching; vulvar excoriation, inflammation, burning, itching). Therapy may have to be discontinued.
- Note: Use Clinistix or TesTape when monitoring urinary glucose to avoid false readings with diabetes mellitus.
- Do not breast feed while taking this drug without consulting physician.