Classifications: antiinfective; antibiotic; second-generation cephalosporin
Prototype: Cefonicid sodium
Pregnancy Category: B
Assessment & Drug Effects
- Determine history of hypersensitivity reactions to cephalosporins, penicillins, and history of allergies, particularly to drugs, before therapy is initiated.
- Lab tests: Perform culture and sensitivity tests before initiation of therapy and periodically during therapy if indicated. Therapy may be instituted pending test results. Monitor periodically BUN and creatinine clearance.
- Inspect IM and IV injection sites frequently for signs of phlebitis.
- Report onset of loose stools or diarrhea. Although pseudomembranous colitis (see Signs & Symptoms, Appendix F) rarely occurs, this potentially life-threatening complication should be ruled out as the cause of diarrhea during and after antibiotic therapy.
- Monitor for manifestations of hypersensitivity (see Appendix F). Discontinue drug and report their appearance promptly.
- Monitor I&O rates and pattern: Especially important in severely ill patients receiving high doses. Report any significant changes.
Patient & Family Education
- Report loose stools or diarrhea promptly.
- Report any signs or symptoms of hypersensitivity (see Appendix F).
- Do not breast feed while taking this drug.